Recombinatie STAT5b

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Stat5B

P51692

Human; Mouse; Rat

Recombinant Human STAT5b protein

STAT; STAT5; STAT5B; Signal Transducer and Activator of Transcription 5B; signal transducer and activator of transcription 5B; STAT5

6G14

Unconjugated

WB

Signal Transduction; Epigenetics and Nuclear Signaling; Cancer; Metabolism

Protein A

0.2 mg/mL

WB 1:2000-1:10000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/0dvzKzxF

90 kDa

90 kDa

IgG, κ