Recombinatie SUV39H1 monoklonaal antilichaam

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro) . H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length.

SUV39H1

O43463

Human; Mouse

Recombinant human SUV39H1 fragment

SUV39H1; H3-K9-HMTase 1; KMT1A; MG44; SUV39H; H3-K9-HMTase1

A372

Unconjugated

WB

Epigenetics and Nuclear Signaling; Microbiology; Cancer

Protein A purified

1 mg/mL

WB 1:500-1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/2EXzIkcB

48 kDa

48 kDa

IgG, κ