Recombinatie TRIAD1 monoklonaal antilichaam

The E3 ubiquitin-protein ligase ARIH2 (TRIAD1) is an Ariadne subfamily ligase involved in the polyubiquitination of proteins designated for proteasomal degradation. The TRIAD1 nuclear protein contains an amino-terminal acidic region, a pair of RING fingers, two carboxyl terminal coiled coil domains and a novel C6HC DRIL/IBR domain located between the RING fingers. Together, the paired RING fingers and DRIL/IBR domain form a highly conserved TRIAD (two RING fingers and DRIL) domain. Research studies suggest that TRIAD1 mediates both Lys48 and Lys63 protein polyubiquitination and acts as a negative regulator of myelopoiesis. TRIAD1 ubiquitin ligase inhibits myeloid cell proliferation by mediating protein ubiquitination through the ubiquitin-conjugating enzymes UbcH7 and UbcH13. Experimental deletion of TRIAD1 in mice has a lethal effect, leading to death at the embryonic stage or later due to a severe, multi-organ inflammatory response. Results indicate that TRIAD1 binds IκBβ in dendritic cells and promotes the degradation of the NF-κB inhibitor.

TRIAD1

O95376

Human

Peptide. This information is proprietary to PTMab.

ARI; ARIH; TRIAD; ARI2; TRIAD1; ARIH2; HT005; all trans retinoic acid inducible RING finger; Ari 2; Ari-2; Ariadne 2; Ariadne 2 protein homolog; ariadne homolog 2; ariadne homolog 2 (Drosophila) ; Ariadne RBR E3 ubiquitin protein ligase 2; ARIH 2; E3 ubiquitin protein ligase ARIH2; E3 ubiquitin-protein ligase ARIH2; protein ariadne 2 homolog; Protein ariadne-2 homolog; Triad 1; Triad1 protein; UIP48

A763

Unconjugated

WB

Epigenetics and Nuclear Signaling; Cell Biology

Protein A purified

1 mg/mL

WB 1:1000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/mXNS0bso

58 kDa

58 kDa

IgG, κ