Recombinatie XBP1 monoklonaal antilichaam

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1) . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S), which is the functionally active transcription factor.

XBP1

P17861

Human; Mouse; Rat

Recombinant Human XBP1 protein

CBX; X-box-binding protein; Tax responsive element binding protein; Tax-responsive element-binding protein; XBP; XBP1; TREB-5; TREB5; XBP-1; XBP2; XBP1s; CBX1; Tax responsive element binding protein 5; Tax-responsive element-binding protein 5; X box binding protein 1; X box binding protein 2; X-box-binding protein 1; XBP 1

12B12

Unconjugated

WB; IHC

Epigenetics and Nuclear Signaling

Protein A

0.2 mg/mL

IHC 1:200-1:1000; WB 1:1000-1:5000

PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

Ice bag

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

https://789.bio/eb/aSaPKQVS

29 kDa

35 kDa,60 kDa

IgG, κ