Rel-Cleroindicine F

Rel-Cleroindicin F (Rengyolone) is a cyclohexyl acetyl compound that can be isolated from the fruit of forsythia and has anti-inflammatory activity. It strongly inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α). rel-Cleroindicin F does this by downregulating the activity of NF-κB and NF-κB kinases in RAW 264.7 cells stimulated by LPS , thus inhibiting the expression of inducible nitric oxide synthase (NO Synthase) and nitric oxide production[1].

94535-01-0

Rengyolone

12352005

NF-κB; NO Synthase; TNF Receptor

Apoptosis; Immunology/Inflammation; NF-κB

Inflammation/Immunology

O[C@@]12[C@@](OCC2)([H])CC(C=C1)=O

C8H10O3

154.16

[1]Jin Hee Kim, et al. Rengyolone inhibits inducible nitric oxide synthase expression and nitric oxide production by down-regulation of NF-kappaB and p38 MAP kinase activity in LPS-stimulated RAW 264.7 cells. Biochem Pharmacol. 2006 Apr 14;71 (8) :1198-205.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N3602A/

Natural Products

No Development Reported