Relax-2

Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

H2 relaxin, RLN2

6019

P04090

NP_005050.2

NM_005059.3

Human

Human

A-Chain: QLYSALANKC CHVGCTKRSL ARFC; B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Data not available.

53

Lyophilized

6.0 kDa

E. coli