RELB Antilichaam - middengebied HRP (ARP38808_P050-HRP)

V-rel reticuloendotheliosis viral oncogene homolog B

IREL, I-REL, IMD53, REL-B

5971

Q01201

NP_006500

Human, Cow, Dog, Horse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human RELB

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.

NFKB2; NFKB1; BCL3; NEK6; DNMT1; DAXX; MT1M; GSK3B; CTSL; CDK1; BUD31; UQCRFS1; MTAP; COMMD9; COMMD5; MALT1; COMMD1; COMMD8; COMMD4; COMMD10; COMMD2; UBC; RAC1; SUZ12; RELA; EZH2; DPF2; YY1; CBX3; EHMT2; NFKBIA; KPNA6; SMARCA4; SMARCE1; SMARCC2; SMARCC1

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Horse: 93%; Human: 100%; Pig: 86%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

62kDa

Mattei, M.G., (er) Ann. Rheum. Dis. (2008) In press

Wet Ice

579

RELB

RELB

Rabbit

Transcription factor RelB

NM_006509

DLLPPAPPHASAVVCSGGAGAVVGETPGPEPLTLDSYQAPGPGDGGTASL