Renin Antilichaam

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.

5972

P00797

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 24-160 of human Renin (NP_000528.1) .

Unconjugated

Primary Antibodies

Other

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 45kDa

IgG

REN

HT-29

SKOV3

Mouse kidney

Mouse skin

Renin

Homo sapiens

REN, FLJ10761, HNFJ2

WB, IHC

Liquid