RepSox (hydrochloride)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) . RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
2319939-07-4
E-616452 (hydrochloride) ; SJN 2511 (hydrochloride)
12352005
Anaplastic lymphoma kinase (ALK) ; TGF-beta/Smad
Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Metabolism-protein/nucleotide metabolism
Metabolic Disease
CC1=NC(C2=NNC=C2C3=CC=C4N=CC=CC4=N3)=CC=C1.Cl
C17H14ClN5
323.78
[1]Gellibert F, et al. Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem. 2004 Aug 26;47 (18) :4494-506.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W707119/
Reference compound1
No Development Reported
Beschrijving
RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) . RepSox hydrochloride
Specificaties
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