REQUIEM Antilichaam

REQUIEM Antibody: Requiem is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It is expressed in numerous tissues in both cytosolic and nuclear regions and likely serves a regulatory role in rapid hematopoietic cell growth and turnover. Requiem has been found to act as an adaptor protein that links the NF-κ B and SWI/SNF chromatin remodeling factor and is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.

5977

Q92785

AAB81203

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

REQUIEM Antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (94%)

REQUIEM Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

REQUIEM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Requiem antibody is predicted to not cross-react with other DPF protein family members.

DPF2

Cat. No. 10-401 - Human Kidney Tissue Slide

D4, zinc and double PHD fingers family 2

Homo sapiens

Gabig TG, Mantel PL, Rosli R, et al. Requiem: a novel zinc finger gene essential for apoptosis in myeloid cells. J. Biol. Chem.1994; 269:29515-9.

Gabig TG, Crean CD, Klenk A, et al. Expression and chromosomal localization of the Requiem gene. Mamm. Genome1998; 9:660-5.

Tando T, Ishizaka A, Watanable H, et al. Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. J. Biol. Chem.2010; 285:21951-60.

REQUIEM Antibody: REQ, UBID4, ubi-d4, BAF45D, REQ, Zinc finger protein ubi-d4, Apoptosis response zinc finger protein

ELISA, WB, IHC-P, IF

5454004

Liquid