RES-701-1

RES-701-1 is a cyclic peptide composed of 16 common L-amino acids, acting as a specific antagonist for the ETB receptor. RES-701-1 can inhibit the binding of 125I-ET-1 (125I-labeled Endothelin (ET) -1) to the ETB receptor, with an IC50 value of 10 nM[1][2].

151308-34-8

12352209

Endothelin Receptor

GPCR/G Protein

Neuroscience-Neuromodulation

Cardiovascular Disease

OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CC=C(C=C4)O)=O)NC([C@H](CC(N)=O)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC6=CC=CC=C6)NC([C@@H](NC([C@H]7NC([C@@]8([H])N(C([C@@H](NC([C@](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(C7)=O)=O)CC(N)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O)CC%11=CN=CN%11)=O)=O)([H])[C@H](O)C)=O)C)=O)CCC8)=O)=O)CC%12=CNC%13=CC=CC=C%12%13)=O)=O)=O)=O

C103H115N23O23

2043.16

[1]Tanaka T, et al. RES-701-1, a novel, potent, endothelin type B receptor-selective antagonist of microbial origin. Mol Pharmacol. 1994 Apr;45 (4) :724-30.|[2]Yamasaki M, et al. RES-701-1, a novel and selective endothelin type B receptor antagonist produced by Streptomyces sp. RE-701 II. Determination of the primary sequence[J]. The Journal of Antibiotics, 1994, 47 (3) : 276-280.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10135/

Peptides

No Development Reported

ETB