Oplossen van E1

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA) . Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].

552830-51-0

RvE1

12352211

H302, H315, H319, H335

Endogenous Metabolite

Natural Products

Metabolic Enzyme/Protease

COVID-19-immunoregulation

Inflammation/Immunology

https://www.medchemexpress.com/resolvin-e1.html

285.3 μM * 250 μL in Ethanol

98.1

Ethanol : 50 mg/mL (ultrasonic; warming)

CC[C@@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O

C20H30O5

350.45

H302, H315, H319, H335

[1]Arita M, et al. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24;102 (21) :7671-6.|[2]Schwab JM, et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14;447 (7146) :869-74.|[3]Hasturk H, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissuehomeostasis in vivo. J Immunol. 2007 Nov 15;179 (10) :7021-9.

Blue Ice

Solution, -20°C, 2 years

http://file.medchemexpress.com/batch_PDF/HY-114041/Resolvin-E1-SDS-MedChemExpress.pdf

Natural Products

No Development Reported

Human Endogenous Metabolite