RET-antilichaam - C-terminaal gebied: Biotine (ARP30878 P050-Biotine)

Ret proto-oncogene

PTC, MTC1, HSCR1, MEN2A, MEN2B, CDHF12, CDHR16, RET-ELE1

5979

P07949

NP_000314

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

NOTCH2NL; UBC; CBLC; PDLIM7; HSP90AA1; GRB2; CBL; RET; MCRS1; IKBKG; DOK3; DOK5; DOK4; DOK6; SHC3; FRS2; DOK2; AKAP5; CBLB; GAB1; DOK1; NRTN; MAPK3; GRB10; GRB7; GFRA1; MAPK8; GDNF; PTK2; SHC1; MAPK14; SRC; MAPK1; PRKAR2A; PTPN11; PLCG1; PIK3R1; CRK; STAT

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 90%; Horse: 100%; Human: 100%; Mouse: 90%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

123kDa

Wet Ice

1114

RET

RET

Rabbit

Proto-oncogene tyrosine-protein kinase receptor Ret

NM_000323

EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK