RFC4 Antilichaam - middengebied: Biotine (ARP46087_P050-Biotine)

Replication factor C (activator 1) 4, 37kDa

A1, RFC37

5984

P35249

NP_002907

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human RFC4

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) . RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.

RNF41; UBC; RFC5; PCNA; TP53; SUMO2; RPA3; RPA2; RPA1; RNF2; C14orf166; RTCB; RPL26L1; DIMT1; NELFB; EDC4; IGF2BP3; EIF2B2; EIF2B3; YBX3; QARS; NMT1; HNRNPM; MRE11A; ILF2; HNRNPU; FLII; FKBP3; EPRS; DHX9; DDX1; ABCF1; PARK2; TARDBP; MPG; RFC2; MYC; FN1; P

Biotin

Polyclonal Antibody

WB

Affinity Purified

RFC4 is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Dog: 86%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

40kDa

Gupte, R.S., (2005) Cell Cycle 4 (2), 323-329

Wet Ice

363

RFC4

RFC4

Rabbit

Replication factor C subunit 4

NM_002916

DKLEAVVKDLIDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDK

4