RFX1 Antilichaam

RFX1 is a member of the regulatory factor X protein family, which are transcription factors that contain a highly-conserved winged helix DNA binding domain and the D region found in the C-terminal part of these proteins which facilitates dimerization (1,2) . RFX1 is structurally related to regulatory factors X2, X3, X4, and X5 (3) . RFX1 is a regulatory factor essential for MHC class II genes expression and can bind to an inverted repeat that is required for expression of hepatitis B virus genes (4) . Recent study identifies RFX1 may play a tumor suppressor role in HCC as autophagy mediator (5) .

5989

P22670

NP_002909

Human

Unconjugated

Primary Antibodies

Immunology, Autophagy

RFX1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (89%)

RFX1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RFX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Multiple independent RFX1 antibodies also show a band at ~130 kDa

IgG

RFX1 antibody is human specific. At least two isoforms of RFX1 are known to exist; this antibody will detect both isoforms.

RFX1

Cat. No. 17-001 - HeLa Cell Slide

Regulatory factor X, 1 (influences HLA class II expression)

Homo sapiens

Reith W, Ucla C, Barras E, et al. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol. Cell Biol. 1994; 14:1230-44.

Katan-Khaykovich Y and Shaul Y. RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. J. Biol. Chem. 1998; 273:24504-12.

Hsu YC, Liao WC, Kao CY, et al. Regulation of FGF1 gene promoter through transcription factor RFX1. J. Biol. Chem. 2010; 285:13885-95.

Su JC, Tseng PH, Hsu CY, et al. RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget 2014; 5:4909-19.

RFX, MHC class II regulatory factor RFX, MHC class II regulatory factor RFX1, enhancer factor C, EFC, trans-acting regulatory factor 1, transcription factor RFX1

ELISA, WB, ICC, IF

238859557

Liquid