RFX1 Antilichaam - middengebied: Biotine (ARP38200 P050-Biotine)

Regulatory factor X, 1 (influences HLA class II expression)

EFC, RFX

5989

P22670

NP_002909

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human RFX1

RFX1 is a member of the regulatory factor X protein family, which are transcription factors that contain a highly-conserved winged helix DNA binding domain. RFX1 is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

SOX2; SMAD9; SMAD4; SMAD1; NOTCH1; Cebpb; NCOA3; HDAC1; NFIC; NFIB; TADA3; RFX3; MAGED1; ABL1; NFIX; HMGB1; HIVEP2; RFX2; ADD1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 90%; Human: 100%; Mouse: 100%; Rat: 100%; Yeast: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

105kDa

Wang, K.R., (2007) J. Biol. Chem. 282 (36), 26167-26177

Wet Ice

979

RFX1

RFX1

Rabbit

MHC class II regulatory factor RFX1

NM_002918

EDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVP