RGR Antilichaam

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively) .

5995

P47804

P47804

Human

This RGR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-291 amino acids from the Central region of human RGR.

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction, Growth Factors

This antibody is purified through a protein A column, followed by peptide affinity purification.

Batch dependent

Supplied in PBS with 0.09% (W/V) sodium azide.

None

Blue Ice

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

32 kDa

Rabbit Ig

RGR

RPE-retinal G protein-coupled receptor

Homo sapiens

Kochounian, H., et al. Exp. Eye Res. 88 (6) :1129-1136 (2009)

Radu, R.A., et al. J. Biol. Chem. 283 (28) :19730-19738 (2008)

Luttrell, L.M. Mol. Biotechnol. 39 (3) :239-264 (2008)

Lin, M.Y., et al. Mol. Vis. 13, 1203-1214 (2007)

RPE-retinal G protein-coupled receptor, RGR

WB, IHC-P, Flow

1350592

Liquid