RHBDD2 Antilichaam

RHBDD2 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.

57414

Q6NTF9

NP_001035546

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

RHBDD2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1462 - Rat Lung Tissue Lysate

1 mg/mL

RHBDD2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RHBDD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

RHBDD2

Rhomboid domain containing 2

Homo sapiens

Koonin EV, Makarova KS, Rogozin IB, et al. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple horizontal gene transfers. Genome Biol.2003; 4:R19.

Abba MC, Sun H, Hawkins KA, et al. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol. Cancer Res.2007; 5:881-90.

Abba MC, Lacunza E, Nunez MI, et al. Rhomboid domain containing 2 (RHBDD2) : a novel cancer-related gene over-expressed in breast cancer. Biochim. Biophys. Acta2009; 1792:988-97.

Wang Y, Guan X, Fok KL, et al. A novel member of the rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol. Life Sci.2008; 65:3822-9.

RHBDD2 Antibody: NPD007, RHBDL7, Rhomboid domain-containing protein 2

ELISA, WB, IF

94818790

Liquid