RI-OR2-TAT

RI-OR2-TAT is a brain-penetrant inhibitor of β-Amyloid oligomerization, which is produced by adding the HIV protein transduction domain TAT to RI-OR2. RI-OR2-TAT binds to Aβ42 fibrils with a Kd value of 58-125 nM. RI-OR2-TAT reduces Aβ aggregation and plaque levels, reduces activation of microglia and oxidative damage, and increases the number of young neurons in the dentate gyrus[1].

1430219-69-4

12352209

Amyloid-β

Neuronal Signaling

Neurological Disease

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C117H201N49O23

2662.16

[1]Doig AJ, et al. Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol. 2015 Feb;30:50-56.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10824/

Peptides

No Development Reported