RIC8A Antibody - N-terminal regio : HRP (ARP57567 P050-HRP)

Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)

RIC8

60626

Q9NPQ8-3

NP_068751

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human RIC8A

RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex. RIC8A also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation.

NECAB2; UBQLN1; RABAC1; UBC; EFEMP1; SDCBP; NUTM1; SARNP; WDR61; DPP7; PAPSS2; EZR; UBA1; RPL38; PYGB; PLCG1; MC1R; APEX1; GNAQ; XPO1; GNAI1; UBQLN4; ZNF585B; RIC8A; MAPK8IP3; GNA13; TERF1; GNAI3; GNAI2; GNAS; GNAO1; TUBB2A

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

60kDa

Wet Ice

537

RIC8A

RIC8A

Rabbit

Synembryn-A

NM_021932

KLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLL