RIG-1 Antilichaam

RIG-1 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKε through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.

23586

O95786

O95786

Human, Mouse, Rat

RIG-1 antibody was raised against human GST-tagged RIG-1 protein.

Unconjugated

Primary Antibodies

Infectious Disease

RIG-1 Antibody is Protein A purified.

Cat. No. 1285 - C2C12 Cell Lysate

1 mg/mL

RIG-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RIG-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

DDX58

Cat. No. 1301 - Human Heart Tissue Lysate

Cat. No. 10-501 - Human Heart Tissue Slide

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58

Homo sapiens

Akira S, Uematsu S, and Takeuchi O. Pathogen recognition and innate immunity. Cell 2006; 124:783-801.

Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 2004; 5:730-7.

Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413:732-8.

Sharma S, tenOever BR, Grandvaux N, et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 2003; 300:1148-51.

RIG-1 Antibody: RIGI, RIG-I, RLR-1, Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58

ELISA, WB, IHC-P

81170421

Liquid