Riluzole-13C6

Riluzole-13C6 (PK 26124-13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.

PK 26124-13C6

12352005

GABA Receptor; Isotope-Labeled Compounds; Sodium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Cancer-programmed cell death

Neurological Disease; Cancer

NC1=N[13C]2=[13C][13C]=[13C](OC(F)(F)F)[13C]=[13C]2S1

C2 13C6H2F3N2OS

237.13

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA (A) receptor function. Neuropharmacology. 2002 Feb;42 (2) :199-209.|[3]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 28;11:51.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0211S1/

Isotope-Labeled Compounds

No Development Reported