Rizatriptan

Rizatriptan (MK 462 free base) is an orally active, potent and selective 5-HT1D receptor agonist. Rizatriptan is promising for research of migraine[1].

144034-80-0

MK 462 (free base)

12352005

H302-H315-H319-H335

5-HT Receptor

GPCR/G Protein; Neuronal Signaling

Neuroscience-Neuromodulation

Neurological Disease

CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3

C15H19N5

269.34

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Street LJ, et al. Synthesis and serotonergic activity of N, N-dimethyl-2-[5- (1,2,4-triazol-1-ylmethyl) -1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J Med Chem. 1995 May 12;38 (10) :1799-810.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W018475/

Reference compound1

Launched

5-HT1 Receptor