RLN3 Antilichaam

Relaxin-3 (RLN3) is a member of Relaxin family, a group of endocrine and autocrine/paracrine hormones that belong to the insulin gene superfamily (1,2) . RLN3 can bind to and activate three relaxin-family peptide receptors: RXFP1, RXFP3, and RXFP4 (3) . In contrast to the widespread expression of the related proteins RLN1 and RLN2, RLN3 is predominantly expressed in brain and to a lesser extent in the thymus, kidney and spleen (1) . RLN3 has been suggested to play a role in feeding, metabolism, stress, arousal, learning, and memory (4) .

117579

Q8WFX3

NP_543140

Human

Unconjugated

Primary Antibodies

Signal Transduction, Neuroscience

RLN3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (89%), Rat: (84%)

RLN3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RLN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

RLN3 antibody is human specific. RLN3 antibody is predicted to not cross-react with other members of the Relaxin protein family.

RLN3

Cat. No. 10-301 - Human Brain Tissue Slide

Relaxin 3

Homo sapiens

Bathgate RA, Samuel CS, Burazin TC, et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J. Biol. Chem. 2002; 277:1148-57.

Wilkinson TN and Bathgate RA. The evolution of the relaxin peptide family and their receptors. Adv. Exp. Med. Biol. 2007; 612:1-13.

Silvertown JD, Neschadim A, Liu HN, et al. Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. Regul. Pept. 2010; 159:44-53.

Bathgate RAD, Halls ML, van der Westhuizen ET, et al. Relaxin family peptides and their receptors. Physiol. Rev. 2012; 93:405-80.

Relaxin-3, RXN3, H3, ZINS4, INSL7

ELISA, WB, IHC-P, IF

18254464

Liquid