RNASET2 Antilichaam

RNASET2 Antibody: RNASET2 is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement, and has been suggested to function as a tumor suppressor protein. Its expression is suppressed in Human T-cell Leukemia Virus type 1 (HTLV-1) infected cells following the binding of the HTLV-1 Tax protein to the RNASET2 promoter. As Adult T-cell leukemia (ATL) is one of the primary diseases caused by HTLV-1 infection, a reduction in the level of RNASET2 by Tax may play a role in ATL development.

8635

O00584

NP_003721

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

RNASET2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1221 - SW480 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%)

RNASET2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RNASET2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

RNASET2

Ribonuclease T2

Homo sapiens

Acquati F, Morelli C, Cinquetti R, et al. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. Oncogene 2001; 20:980-8.

Campomenosi P, Salis S, Lingqvist C, et al. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. Arch. Biochm. Biophys. 2006; 449:17-26

Polakowski N, Han H, and Lemasson I. Direct inhibition of RNase T2 expression by the HLTV-1 viral protein Tax. Viruses 2011; 3:1485-500.

RNASET2 Antibody: RNASE6PL, bA514O12.3, RNASE6PL, Ribonuclease T2, Ribonuclease 6

ELISA, WB, ICC, IF

5231228

Liquid