RNF125 Polyklonale Antilichaam, AbBy FluorTM 750 Vervoeging

The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. TRAC-1 (T-cell RING activation protein 1), also known as RNF125 (ring finger protein 125) or E3 ubiquitin-protein ligase RNF125, is a 232 amino acid novel E3 ubiquitin ligase that functions as a positive regulator in the T-cell receptor signaling pathway. Expressed predominantly in lymphoid tissues such as spleen, thymus and bone marrow, TRAC-1 has been found to inhibit pathogen-induced cytokine production and down-regulates HIV replication.

T cell RING activation protein 1; E3 ubiquitin protein ligase RNF125; Ring finger protein 125; RNF 125; T cell ring protein identied in activation screen; TRAC 1; TRAC1; RN125_HUMAN.

9611

Human, Mouse, Rat

1-100/232

RNF125

AbBy Fluor™ 750

KLH conjugated synthetic peptide derived from human TRAC1/RNF125

WB, IF

Purified by Protein A.

749nm/775nm

1µg/µl

WB (WB=1:500-2000), IF (IF=1:50-200)

Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

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