RNF128 Antilichaam - C-terminalgebied: Biotine (ARP43311_T100-Biotine)

Ring finger protein 128, E3 ubiquitin protein ligase

GRAIL

79589

Q8TEB7

NP_919445

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human RNF128

RNF128 is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of RNF128 in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of RNF128 was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype.The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

CEP76; APPBP2; TP53; UBE2H; UBE2E1; UBE2D1; Arhgdia; Arhgdib; RNF128; UBE2T; UBE2I; UBE2N; CD40LG; OTUB1; USP8

Biotin

Polyclonal Antibody

WB

RNF128 is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Cow: 86%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Soares, L., (2004) Nat. Immunol. 5 (1), 45-54

Wet Ice

428

RNF128

RNF128

Rabbit

E3 ubiquitin-protein ligase RNF128

NM_194463

LEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREI