RNF14 Antilichaam - C-terminaal gebied: Biotine (ARP38448 T100-Biotine)

Ring finger protein 14

ARA54, HFB30, TRIAD2, HRIHFB2038

9604

Q9UBS8

NP_899648

Human, Rat, Cow, Dog, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human RNF14

RNF14 contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins.The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.

UBE2E2; UBE2D1; DACH1; UBE2D4; LEF1; TCF3; HNF1A; TCF4; CTNNB1; UBC; AR; FAM46A; TNFAIP3; ECT2; UBE2E3; UBE2E1; PHF7; TAGLN; HNRNPA1; VDR; UBE2D3; UBE2D2; UBE2U; UBE2W; UBE2V1; NCOA4; NR3C1; ESR1; RNF14

Biotin

Polyclonal Antibody

IHC, WB

0.5 mg/ml

Cow: 79%; Dog: 79%; Human: 100%; Rabbit: 79%; Rat: 79%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

Lin, D.Y., (2004) Mol. Cell. Biol. 24 (24), 10529-10541

Wet Ice

474

RNF14

RNF14

Rabbit

E3 ubiquitin-protein ligase RNF14

NM_183401

CMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED