RNF20 Antilichaam

RNF20 Antibody: RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) . In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

56254

Q5VTR2

NP_062538

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

RNF20 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (89%)

RNF20 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RNF20 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Multiple isoforms of RNF20 are known to exist.

RNF20

Cat. No. 10-201 - Human Liver Tissue Slide

Ring finger protein 20, E3 ubiquitin protein ligase

Homo sapiens

Zhu B, Zheng Y, Pham AD, et al. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 2005; 20:601-11.

Shema E, Kim J, Roeder RG, et al. RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell 2011; 42:477-88.

Shema E, Tirosh I, Aylon Y, et al. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes Dev. 2008; 22:2664-76.

Fuchs G, Shema E, Vesterman R, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol. Cell 2012; 46:662-73.

RNF20 Antibody: BRE1, BRE1A, hBRE1, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20, BRE1-A

ELISA, WB, IHC-P, IF

34878777

Liquid