RNF20 (NM 019592) Humaan Recombinant eiwit

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) . [provided by RefSeq, Feb 2012]

Purified recombinant protein of Human ring finger protein 20 (RNF20), Glu493-Arg754, with N-terminal His tag, expressed in E. coli, 50ug

BRE1; BRE1A; hBRE1

56254

Q5VTR2

NM_019592

9q31.1

E. coli

N-His

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Druggable Genome

31.1 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

RNF20

Human

NP_062538

https://www.ncbi.nlm.nih.gov/gene/56254

https://www.uniprot.org/uniprot/Q5VTR2

https://www.ncbi.nlm.nih.gov/nuccore/NM_019592

https://www.ncbi.nlm.nih.gov/nuccore/NP_062538