RNF34 Antilichaam - middengebied: Biotine (ARP40158_P050-Biotine)

Ring finger protein 34, E3 ubiquitin protein ligase

RFI, RIF, RIFF, hRFI, CARP1, CARP-1

80196

Q969K3

NP_079402

Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human RNF34

RNF34 contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis.The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

APPBP2; NOD1; APP; PRKACB; PHF7; TRIM23; UBE2D2; CASP10; CASP8; FZR1; ANAPC2; CDC20; SH3KBP1; PPARGC1A; TP53; UBE2F; UBE2H; DNAJA3

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 87%; Dog: 93%; Guinea Pig: 80%; Horse: 93%; Human: 100%; Rabbit: 80%; Rat: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

42kDa

Konishi, T., (2005) Mol. Cancer Ther. 4 (5), 743-750

Wet Ice

372

RNF34

RNF34

Rabbit

E3 ubiquitin-protein ligase RNF34

NM_025126

LVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSFFSNYTAPSATMSS