RNF62/MKRN2 Polyklonale Antilichaam, PE-vervoeging

The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the C-terminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines.

HSPC070_ Makorin 2; Makorin ring finger protein 2; Makorin2; Makorin-2 MKRN 2; RING finger protein 62; RNF 62; RNF62; MKRN2_HUMAN; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62.

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Human, Mouse, Rat

261-360/416

RNF62/MKRN2

PE

KLH conjugated synthetic peptide derived from human MKRN2/RNF62

IF

Purified by Protein A.

496,564nm/578nm

1µg/µl

IF ()

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

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