RNF8 Polyklonal Antibody, Biotin Conjugated

The RING finger motif is a specialized DNA-binding zinc finger domain found in many transcriptional regulatory proteins. The ring finger protein (RNF) family includes any protein containing the signature RING finger motif. RNF8 is a ubiquitously expressed nuclear RING finger protein that acts as an E3 ubiquitin-protein ligase. It is required for the ubiquitination of some nuclear proteins and promotes their subsequent degradation. The heterodimeric ubiquitin-conjugating enzyme UBC13 interacts with RNF8, and they co-localize in the nucleus. RNF8 may regulate mediation of UBC13 polyubiquitylation by elongating the ubiquitin chains. RNF8 also binds to Retinoid X receptor alpha (RXR?, a member of the steroid hormone receptor superfamily. It increases RXR?mediated transactivation of the RXR?responsive element (RXRE) promoter in a dose-dependent manner, suggesting that RNF8 is a regulator of RXR?mediated transcriptional activity.

C3HC4 type zinc finger protein; E3 ubiquitin protein ligase RNF8; E3 ubiquitin-protein ligase RNF8; Ring finger protein C3HC4 type 8; RING finger protein 8; RNF 8; RNF8; RNF8_HUMAN; UBC13/UEV interacting ring finger protein.

9025

Mouse

331-430/485

RNF8

Biotin

KLH conjugated synthetic peptide derived from human RNF8

WB, IHC-P

Purified by Protein A.

1µg/µl

WB (1:300-5000), IHC-P (1:200-400)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

9025

Human, Rat, Dog, Pig, Horse