
RO5323441
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) targeting PlGF. RO5323441 inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1 (IC50 values are 0.1 and 0.2 nM, respectively) . RO5323441 blocks PlGF-induced VEGFR-1 phosphorylation in Flt-1-transfected HEK293 cells. RO5323441 has antitumor activity[1].
TB-403
12352203
VEGFR
Protein Tyrosine Kinase/RTK
Cancer-Kinase/protease
Cancer
[RO5323441]
[1]Rizzo C, et al. RO5323441, a humanized monoclonal antibody against the placenta growth factor, blocks PlGF-induced VEGFR-1 phosphorylation in vitro and tumor growth in vivo[J]. Cancer Research, 2010, 70 (8_Supplement) : 1370-1370.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991430/
Inhibitory Antibodies
No Development Reported
Beschrijving
RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) targeting PlGF. RO5323441 inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1 (IC50 values ar
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