Ropinirol-d3

Ropinirole-d3 (SKF 101468-d3) is deuterium labeled Ropinirole. Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

1132746-02-1

SKF 101468-d3

12352005

Dopamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

CCCN(CCC)CCC1=C2C(NC(C2)=O)=C([2H])C([2H])=C1[2H]

C16H21D3N2O

263.39

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38 (1) : p. 147-54.|[3]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17 (12) :1981-93.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0623S1/

Isotope-Labeled Compounds

No Development Reported