Ropinirol-d4 (hydrochloride)

Ropinirole-d4 (SKF 101468-d4) hydrochloride is the deuterium labeled Ropinirole hydrochloride. Ropinirole hydrochloride is a potent D3/D2 receptor agonist with a Kiof 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2].

1330261-37-4

SKF 101468-d4 (hydrochloride)

12352005

Dopamine Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

10 mM in DMSO

C(CN(C(CC)([2H])[2H])C(CC)([2H])[2H])C1=C2C(NC(=O)C2)=CC=C1.Cl

C16H21D4ClN2O

300.86

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38 (1) : p. 147-54.|[3]Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17 (12) :1981-93.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0623AS/

Isotope-Labeled Compounds

No Development Reported

D2 Receptor; D3 Receptor; D4 Receptor