RORγ-IN-2

RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases[1].

2088333-58-6

12352005

H302-H315-H319-H335

ROR

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

COVID-19-immunoregulation

Inflammation/Immunology

CCS(C(C=N1)=CC=C1CNC(C2=CC3=C(C4(O[C@H](C3)C)CCN(CC4)[C@@H](C5=CN=C(C(F)(F)F)N=C5)C)S2)=O)(=O)=O

C28H32F3N5O4S2

623.71

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Lugar CW, et al. Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) . J Med Chem. 2021 May 13;64 (9) :5470-5484.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W545294/

Reference compound1

No Development Reported

RORγ