Roseltide rT1

Roseltide rT1 is a neutrophil elastase inhibitor (IC50=0.47 μM) rich in cysteine and one of the Roseltide (rT1-rT8) family members. Roseltide rT1 improves cAMP accumulation stimulated by neutrophil elastase in vitro, showing potential for inhibiting related diseases[1].

2206692-95-5

12352209

Elastase

Metabolic Enzyme/Protease

Metabolism-protein/nucleotide metabolism

Metabolic Disease

O=C([C@@H](N)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N2[C@H](C(NC3)=O)CCC2)=O)CO)=O)CC(N)=O)=O)N[C@H](C(N4[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]1CSSC[C@H](NC5=O)C(N[C@H](C(O)=O)C)=O)=O)=O)CO)=O)CC(C)C)=O)C)=O)C(C)C)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]5[C@H](CC)C)=O)=O)CC6=CC=CC=C6)=O)[C@H](CC)C)=O)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)CCC4)=O)[C@H](CC)C

C110H177N31O31S6

2622.16

[1]Loo S, et al. Identification and Characterization of Roseltide, a Knottin-type Neutrophil Elastase Inhibitor Derived from Hibiscus sabdariffa. Sci Rep. 2016 Dec 19;6:39401.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10924/

Peptides

No Development Reported