Roxadustat
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Roxadustat (808118-40-3) is a pan-prolyl hydroxylase domain (PHD) inhibitor (IC50 for PHD2 = 591 nM) 1 that stabilizes hypoxia-inducible factor (HIF) leading to erythropoiesis. Currently in clinical trials for treatment of anemia related to chronic kidney disease.2 Roxadustat accelerated cutaneous wound healing and shortened healing time via improvement in epidermal stem cell proliferation and motility3 and increasing angiogenesis4. It displayed radioprotective effects in haematopoietic systems via up-regulation of HIF-1.5 Roxadustat displayed protective effects against atherosclerosis via activation of adipose HIF-2.6
Unconjugated
Off-white or white solid
-20°C
Beschrijving
Roxadustat Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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