RPRD1B Monoklonale Antilichaam

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN2B or cyclin-A. Promotes cell proliferation.

RPRD1B

Q9NQG5

Human

Recombinant Human RPRD1B Protein

NET; C20orf; dJ1057B; RPRD1B; C20orf77; CREPT; NET60; dJ1057B20.2; K-H; Kub5-Hera

13B3

Unconjugated

IHC-P

Cell Biology

Protein A

1 mg/mL

IHC-P 1:50-1:200

0.2 μm filtered solution in PBS

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/ke54HYXH

IgG2b