RPSA Antilichaam

The 40S ribosomal protein SA (RPSA) is a high-affinity, non-integrin family, laminin receptor, also known as 67 kDa laminin receptor or 37 kDa laminin receptor precursor (37LRP) (1) . Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes and have been implicated in a variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis (2) . RPSA is overexpressed in multiple types of cancers and has recently been shown to act as a cancer-specific death receptor (3) .

3921

P08865

NP_002286

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

RPSA antibody is affinity chromatography purified via peptide column.

Cat. No. 1223 - Caco-2 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (100%), Rat: (100%), Sheep: (100%)

RPSA antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RPSA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

RPSA antibody is human, mouse and rat reactive.

RPSA

Ribosomal protein SA

Homo sapiens

Jackers P, Minoletti F, Belotti D, et al. Isolation from a multigene family of the active human gene of the metastasis-associated 67kDa laminin binding protein 37LRP/p40 at chromosome 3p21.3. Oncogene 1996; 13:495-503.

Savino W and Silva-Barbosa SD. Laminin/VLA-6 interactions and T cell function. Braz. J. Med. Biol. Res. 1996; 29:1209-20.

Kumazoe M, Sugihara K, Tsukamoto S, et al. 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis. J. Clin. Invest. 2013; 123:787-99.

RPSA Antibody: SA, LBP, LRP, p40, 67LR, ICAS, lamR, 37LRP, LAMBR, LAMR1, LRP/LR, LBP/p40, NEM/1CHD4, 40S ribosomal protein SA, 37 kDa laminin receptor precursor

ELISA, WB, IHC-P, IF

9845502

Liquid