RRAS2 Antilichaam

RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55–60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.

22800

P62070

NP_036382

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

RRAS2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

RRAS2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RRAS2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

22 kDa

IgG

Two isoforms of RRAS2 exists as a result of alternative splicing event.

RRAS2

Related RAS viral (r-ras) oncogene homolog 2

Homo sapiens

Ehrhardt A, Ehrhardt GR, Guo X, et al. Ras and relatives--job sharing and networking keep an old family together. Exp. Hematol. 2002; 30:1089-106.

Lowe DG, Capon DJ, Delwart E, et al. Structure of the human and murine R-Ras genes, novel genes closely related to Ras proto-oncogenes. Cell 1987; 48:137-46

Drivas GT, Shih A, Coutavas E, et al. Characterization of four novel Ras-like genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol. 1990;10:1793-8.

Luo H, Hao X, Ge C, et al. TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma. Int. J. Oncol. 2010; 37:853-9

RRAS2 Antibody: TC21, TC21, Ras-related protein R-Ras2, Ras-like protein TC21

ELISA, WB

21361416

Liquid