RSK1 Antilichaam [10B1D7A9 / 10B1D7E12]

Rsk1 is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK proteins possess two separate kinase domains, the C terminal kinase domain and the N terminal kinase domain, separated by a linker region containing a hydrophobic motif. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation.

6195

Q15418

Q15418

Human

Ni-NTA purified truncated recombinant RSK1 expressed in E. Coli strain BL21 (DE3) .

10B1D7A9 / 10B1D7E12

Unconjugated

Primary Antibodies

Signal Transduction

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

RSK1 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2a

RPS6KA1

Ribosomal protein S6 kinase, 90kDa, polypeptide 1

Homo sapiens

Alcorta, D.A., et al. 1989. Mol. Cell. Biol. 9:3850-3859.

Sweet, L.J., et al. 1990. Mol. Cell. Biol. 10: 2413-2417.

MAPKAPK1A, RSK1, 90 kDa ribosomal protein S6 kinase 1, S6K-alpha-1, RSK, HU-1, MAPKAPK1A

ELISA, WB, IHC

20178306