RSPO3 Antilichaam

RSPO3 is a member of the R-spondin family and plays a role in the regulation of Wnt (wingless-type MMTV integration site family) /beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis (1,2) . RSPO3 has been shown to be involved in regulating the balance between angioblast and blood cell specification during embryonic vasculogenesis and angiogenesis and may be involved in tumor development (3,4) .

84870

Q9BXY4

NP_116173

Human, Mouse

Unconjugated

Primary Antibodies

Stem Cell

RSPO3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

RSPO3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RSPO3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

RSPO3 antibody is human and mouse reactive. At least three isoforms of RSPO3 are known to exist; this antibody will detect all three.

RSPO3

Cat. No. 17-010 - HEK293 Cell Slide

R-spondin 3

Homo sapiens

Chen JZ, Wang S, Tang R, et al. Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR. Mol. Biol. Rep. 2002; 29:287-92.

Kim KA, Wagle M, Tran K, et al. R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol. Biol. Cell 2008; 19:2588-96.

Kazanskaya O, Ohkawara B, Heroult M, et al. The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development 2008; 3655-64.

Seshagiri S, Stawiski EW, Durinck S, et al. Recurrent R-spondin fusions in colon cancer. Nature 2012; 488:660-4.

R-spondin-3, CRISTIN1, PWTSR, THSD2

ELISA, WB, ICC, IF

18490982

Liquid