RTDLDSLTTYTL

RTDLDSLRTYTL is an Alpha (v) beta (6) integrin (avb6) inhibitor with high affinity and specificity. RTDLDSLRTYTL binds to avb6 integrin, a peptide sequence that activates cytotoxicity and cytokine production in T cells, such as interferon-gamma. RTDLDSLRTYTL is designed through a chimeric T cell antigen receptor (CAR) so that T cells can be redirected to specifically recognize and attack tumor cells. RTDLDSLRTYTL can be used in the research of cancer immunotherapy and targeted drug development[1].

222557-93-9

12352209

IFNAR; Integrin

Peptides

Cytoskeleton; Immunology/Inflammation

Cancer-programmed cell death

Cancer

https://www.medchemexpress.com/rtdldslrtytl.html

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N

C62H104N18O22

1453.60

[1]Pameijer C R J, et al. Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T cell antigen receptor[J]. Cancer gene therapy, 2007, 14 (1) : 91-97.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10417/

Peptides

No Development Reported