RTP801 Antilichaam

RTP801 Antibody: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC) -dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.

54541

Q9NX09

NP_061931

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

RTP801 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1305 - Human Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

RTP801 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RTP801 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

DDIT4

DNA-damage-inducible transcript 4

Homo sapiens

Ellisen LW, Ramsayer KD, Johannessen CM, et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol. Cell2002; 10:995-1005.

Shoshani T, Faerman A, Mett I, et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol.2002; 22:2283-93.

Wang Z, Malone MH, Thomenius MJ, et al. Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J. Biol. Chem.2003; 278:27053-8.

Sofer A, Lei K, Johannessen CM, et al. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol.2005; 25:5834-45.

RTP801 Antibody: Dig2, REDD1, REDD-1, RTP801, DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801

ELISA, WB, IHC-P, IF

9506687

Liquid