RU 56279

RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells[1][2].

143782-20-1

12352005

H302, H315, H319, H335

Androgen Receptor; Drug Metabolite

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Metabolism-protein/nucleotide metabolism

Cancer; Endocrinology

99.68

CC(C1=O)(C)NC(N1C2=CC(C(F)(F)F)=C(C#N)C=C2)=O

C13H10F3N3O2

297.23

H302, H315, H319, H335

[1]Cousty-Berlin D, et al. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. J Steroid Biochem Mol Biol. 1994 Oct;51 (1-2) :47-55.|[2]Cogan PS, Koch TH. Rational design and synthesis of androgen receptor-targeted nonsteroidal anti-androgen ligands for the tumor-specific delivery of a doxorubicin-formaldehyde conjugate. J Med Chem. 2003 Nov 20;46 (24) :5258-70.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-77833/

Reference compound2

No Development Reported