RU.521
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA.1,2 IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages1 and ~0.80 µM in wild type human THP-1 cells2. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis.3 Active in both mouse and human cell lines.
Unconjugated
Off-white to pale pink solid
-20°C
Beschrijving
RU.521 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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