RUBCN Antibody - middle area : HRP (ARP58950 P050-HRP)

RUN and cysteine rich domain containing beclin 1 interacting protein

SCAR15, RUBICON, KIAA0226

9711

Q92622-2

NP_001139114

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human KIAA0226

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

BECN1; PIK3C3; EXOC8; EXOC2; EXOC1; PIK3R4; UVRAG; YWHAE; SMAD9

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 85%; Dog: 85%; Guinea Pig: 92%; Human: 100%; Mouse: 92%; Rabbit: 85%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

103kDa

Wet Ice

927

RUBCN

RUBCN

Rabbit

Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

NM_001145642

DQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAP