Rubicon Antilichaam

Two Beclin-1-interacting proteins, the run domain Beclin-1 interacting and cysteine-rich containing protein (Rubicon) and ATG14L, reciprocally regulate autophagy at different stages. Knockdown of Rubicon caused enhancement of autophagy while that of ATG14L caused a defect in autophagosome formation (1) . Rubicon functions as part of a Beclin-1-PIK3C3-containing autophagy complex and is also an essential, positive regulator of the NAPDH oxidase complex (2) . Upon microbial infection or TLR2 activation, Rubicon interacts with the CYBA subunit of the NAPDH oxidase complex, leading to a burst of reactive oxygen species and inflammatory cytokines (2) .

9711

Q92622

XP_005269431

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

Rubicon antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

Rubicon antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Rubicon antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Rubicon antibody is human, mouse and rat reactive. Multiple isoforms of Rubicon are known to exist.

KIAA0226

Cat. No. 10-401 - Human Kidney Tissue Slide

KIAA0226

Homo sapiens

Matsunaga K, Saitoh T, Tabata K, et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009; 11:385-96.

Yang CS, Lee JS, Rodgers M, et al. Autophagy protein Rubicon mediates phagocytic NAPDH oxidase activation in response to microbial infection of TLR stimulation. Cell Host and Microbe 2012; 11:264-76.

Run domain Beclin-1 interacting and cysteine-rich containing protein, KIAA0226

ELISA, WB, IHC-P, IF

530375960

Liquid